Now That's What I Call Music! 59 is the 59th edition of the Now! series in the United States. It was released on August 5, 2016. The compilation features 22 tracks, including the Billboard Hot 100 number-one hits "Can't Stop the Feeling!" by Justin Timberlake, "Cheap Thrills" by Sia featuring Sean Paul, and "Panda" by Desiigner.

The album debuted at number 5 on the Billboard 200 with 48,000 units sold in its first week of release. It has sold 124,000 copies in the United States as of September 2016.